Huma IgE ELISA kit 人IgE ELISA試劑盒說(shuō)明書

ntroductionIgE immunoglobulin is a four chain molecule with a mole. Wt. Of ~190 kDa. It is a unique class of immunoglobulin which is important in the mediation of the allergic response. The mechanism of action involves an initial antigenic stimulation of immunocompetent B lymphocytes by a specific antigen, a process which induces the lymphocytes to respond by producing specific antibodies of several classes. Once class of reaginic or IgE antibody, becomes partially bound via its Fc portion to receptors on the surface of mast cells and basophilic leukocytes. Upon further stimulation to specific allergens, these cell-bound IgE molecules bind via their Fab portion to the allergen. This combination triggers the mast cells and basophiles to release, various vasoactive amines into blood and immediately surround tissue. These agents include an increase in vascular permeability, an efflux of blood components and the consequent symptoms characteristics of an allergic reaction. Typical symptoms are inflammation and itching in the case of a bronchial reaction.IgE determinations are valuable in the diagnostic assessment of patients with established or suspected allergic diseases. Studies have shown that conditions such as asthma, rhinitis, eczema, urticaria, dermatitis, and some parasitic infections lead to increased IgE levels